PEPTIDE-VITAMIN-MINERAL RICH COMPLEX
  • Prevents Hair Loss
  • Stimulates new Hair Growth
  • Speeds up Hair Growth
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Patented active ingredients within NUTRIGROW is clinically tested and proven for efficacy with comparable studies to Finasteride and Minoxidil.
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FUNCTION AND CHARACTERISTICS

Fights follicle ageing process to prevent hair loss. NUTRIGROW targets the main causes of alopecia: poor scalp micro-circulation, follicle atrophy caused by dihydrotestosterone and follicle ageing.

Re-starts the interrupted hair cycle to combat Alopecia, stimulates cell proliferation to re-active production of anagen hair, and increases period of shortened anagen phase to prevent miniaturization and hair fall.

DEFINITION

BIOTINLY TRIPEPTIDE
It shows “mitotic activity” aganinst hair loss by stimulating cell metabolism. Activates numerous genes involved in tissue repair mechanism.

OLEANOLIC ACID
Reduces dihydrotestosterone production by inhibiting 5α reductase I and II.

APIGENIN
Improves micro circulation and increases vascular density around the hair follicle in order to facilitate the supply of oxygen and nutrients required for strong hair development.

Anti-Aging HEXAPEPTIDE-11
Targets aging at the cellular level to ensure healthier, more youthful looking hair, increases dermal scalp levels of collagen & elastin.

COPPER, MAGNESIUM, IRON AND ZINC FERMENT
Improves health of hair follicle, stimulates cell differantation, stimulates hair growth. Zinc is an important antioxidant nutrition necessary for healing and development of new cells. Copper is important in the formation of disulfide cross-linkages in keratinization, promoting hair growth.

BIOTIN
Biotin is an essantial vitamin which regulates formation of the late cytokeratins of differentiation. (FRITSCHE et al., 1991) There are various scientific studies which show that Biotin deficiency gives rise to Alopecia.

NIACINAMIDE
A necessary component for the cell metabolism. Participaties in the synthesis of hormones and proteins. Stimulates blood circulation and activates the oxygen transport to hair follicies.

GREEN TEA
Shows anti-aging activity, helps to recover tissue damages.

SACCHARUM OFFICINARUM EXTRACT, CITRUS MEDICA LEMONUM EXTRACT, PYRUS MALUS FRUIT EXTRACT, CAMELLIA SINESIS LEAF EXTRACT
Improves health of hair follicle, removes dead skin cells, promotes cell renewal. Anti inflammatory/anti oxidant activity.

AESCULUS HIPPOCASTANIUM, HORSE CHEST NUT SEED EXTRACT
Prevents excessive seborrhea and itching.

HEXAMIDINE DISETHIONATE
Anti-dandruff, anti-inflammatory.

NUTRIGROW™ provides a protecting and repairing effect on the structure components of the hair follicle, slowing down the aging process.

EFFICACY TESTS

Stimulation Of Cell Metabolism

Mitosis rate
Study of root sheath keratinocytes after a 14-day culture of hair follicles. NUTRIGROW™ active complex (2 ppm) stimulates Ki-67 expression, indicating enhanced cell proliferation.

Gene expression
NUTRIGROW™ active complex activates numerous genes involved in tissue repair mechanisms (DNA-array on 3D SkinEthic epidermis).

Hair anchoring
Hair follicles are incubated for 14 days with NUTRIGROW™ active complex (2 ppm).
Morphological observation of the dermis/root sheath junction.
The persisting dermis/root sheath junction is thick and recovers its normal sinusoidal shape.
Morphological observation of the dermis/root sheath junction.

Stimulation of hair growth
Hair follicles are incubated for 14 days with NUTRIGROW™ active complex (2 ppm).
Under exposure to 2 ppm NUTRIGROW™ active complex, 58% more growth than that of the control was obtained and the growth was similar to that observed in the presence of 2 ppm Minoxidil® (10 µM). With 5 ppm NUTRIGROW™ active complex, the growth was 121% greater than that of the control.

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CLINICAL STUDY

Four-month placebo-controlled clinical trial (Laboratories DERMSCAN)

Principles
A study duration of 4 months was selected in order to totally cover the telogen.
Thirty-five subjects, aged between 18 and 50 years and presenting with more than 20% of their hair in the telogen phase were included.

Product application
The product or placebo was applied twice daily to the scalp using gentle massage.

Compliance / Safety
Compliance and safety visits were conducted after 4, 8 and 12 weeks of treatment. NUTRIGROW active complex was very well tolerated by all volunteers over the 4 months of use.

Videotrichogramme

A/T (Mean value) NUTRIGROW™
Active Complex		 PLACEBO
T0 2.84 2.61
T4 months 3.13 2.54

The A/T ratio increases significantly by up to 46% compared to T0 and the placebo. 67% volunteers had their anagen hair number increased with NUTRIGROW active complex.

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In the NUTRIGROW group 67% of the subjects presented with an improvement in A/T ratio and, for 3 subjects out of the 12 improved, the A/T increase was 31.2, 33.5 and 46,3%, respectively.

In contrast, in the placebo group, there was a trend toward a decrease in anagen hairs.

In fact, a moderate 8% variation of A/T ratio (compared to T0) is reported for Finasteride after 5 months.

Finasteride 1 mg oral tablets 5 Months

  A/T (Mean value)  
T0 Day 1.74  
T5 months 1.88  

Source: Van Neste d et al. 2000 British Dermatol, p.804-10

Hair follicle morphological study

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After treatment, hair bulb cells are highly structured and differentiated. The root sheath is thicker and ensures optimum anchoring.

Morphological changes in the hair after 5 days of Nutrigrow Shampoo application

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Noticeable difference in hair bulb appearance with the NUTRIGROW active complex treatment.

Study of adhesion protein in the dermis /epithelium sheath junction: LAMININ V, COLLAGEN IV

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Activates adhesion proteins by up to %146 (Laminin V and Collagen IV) which are responsible for anchorage in the dermis.

Anti-aging activity on the root sheath

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Mitotic marker Ki67 was used to evidence cell growth activity.
For the control bulb, the results showed a decrease in mitotic keratinocytes on day 14 of culture, reflecting cell aging.
Minoxidil® maintained proliferative activity (as reported by BOYERA et al., 1997), as did 0.3 µM biotinyl-GHK (2 ppm) and approximately 1 µM (5 ppm) Nutrigrow Active Ingredient. The effect obtained with Nutrigrow Active Ingredient was superior in that it was obtained at concentrations 10- to 30-fold lower than the Minoxidil® concentration, 10 µM (2 ppm).